Name: | ABCG2 |
Synonyms: | EST157481, MXR, BCRP, ABCP, CD338 |
Description: | ATP-binding cassette, sub-family G (WHITE), member 2 |
Gene function: | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. |
UTRs: | 9 UTRs found |
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Name: | ADIPOQ |
Synonyms: | ACRP30, AdipoQ, apM1, GBP28, adiponectin,ACDC |
Description: | adiponectin, C1Q and collagen domain containing |
Gene function: | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. |
UTRs: | 4 UTRs found |
Name: | C1QTNF4 |
Synonyms: | CTRP4, ZACRP4 |
Description: | C1q and tumor necrosis factor related protein 4 |
UTRs: | 2 UTRs found |
Name: | C1QTNF6 |
Synonyms: | CTRP6, ZACRP6 |
Description: | C1q and tumor necrosis factor related protein 6 |
UTRs: | 7 UTRs found |
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Name: | CEBPB |
Synonyms: | LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta,TCF5 |
Description: | CCAAT/enhancer binding protein (C/EBP), beta |
Gene function: | Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). |
UTRs: | 3 UTRs found |
Name: | CEBPD |
Synonyms: | CRP3, CELF, C/EBP-delta, NF-IL6-beta |
Description: | CCAAT/enhancer binding protein (C/EBP), delta |
Gene function: | C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages. |
UTRs: | 2 UTRs found |
Name: | CEBPE |
Synonyms: | CRP1 |
Description: | CCAAT/enhancer binding protein (C/EBP), epsilon |
Gene function: | C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. |
UTRs: | 2 UTRs found |
Name: | CLRN1OS |
Synonyms: | UCRP |
Description: | clarin 1 opposite strand |
UTRs: | 2 UTRs found |
Name: | CRIP2 |
Synonyms: | CRP2, ESP1 |
Description: | cysteine-rich protein 2 |
UTRs: | 10 UTRs found |
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Name: | CRP |
Synonyms: | PTX1 |
Description: | C-reactive protein, pentraxin-related |
Gene function: | Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
UTRs: | 5 UTRs found |
Name: | CSPG5 |
Synonyms: | NGC |
Description: | chondroitin sulfate proteoglycan 5 (neuroglycan C) |
Gene function: | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. |
UTRs: | 2 UTRs found |
Name: | CSRP2 |
Synonyms: | SmLIM, CRP2, LMO5 |
Description: | cysteine and glycine-rich protein 2 |
Gene function: | Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. |
UTRs: | 2 UTRs found |
Name: | CSRP2BP |
Synonyms: | CRP2BP, dJ717M23.1, PRO1194 |
Description: | CSRP2 binding protein |
Gene function: | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. |
UTRs: | 6 UTRs found |
Name: | DCAF5 |
Synonyms: | BCRP2, D14S1461E, BCRG2, KIAA1824,WDR22 |
Description: | DDB1 and CUL4 associated factor 5 |
Gene function: | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. |
UTRs: | 8 UTRs found |
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Name: | FAM168A |
Synonyms: | TCRP1,KIAA0280 |
Description: | family with sequence similarity 168, member A |
UTRs: | 6 UTRs found |
Name: | GTF2H2C |
Description: | general transcription factor IIH, polypeptide 2C |
Gene function: | Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II (By similarity). |
UTRs: | 2 UTRs found |
Name: | ISG15 |
Synonyms: | IFI15, UCRP,G1P2 |
Description: | ISG15 ubiquitin-like modifier |
Gene function: | Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. |
UTRs: | 2 UTRs found |
Name: | NCCRP1 |
Synonyms: | LOC342897, NCCRP-1 |
Description: | non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) |
UTRs: | 2 UTRs found |
Name: | NLGN4X |
Synonyms: | KIAA1260, NLGN, HLNX,NLGN4 |
Description: | neuroligin 4, X-linked |
Gene function: | Putative neuronal cell surface protein involved in cell- cell-interactions. |
UTRs: | 2 UTRs found |
Name: | PRSS33 |
Synonyms: | EOS |
Description: | protease, serine, 33 |
Gene function: | Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. |
UTRs: | 2 UTRs found |
Name: | SLC5A9 |
Synonyms: | SGLT4 |
Description: | solute carrier family 5 (sodium/glucose cotransporter), member 9 |
Gene function: | Involved in sodium-dependent transport of D-mannose, D- glucose and D-fructose. |
UTRs: | 2 UTRs found |
Name: | SPAG7 |
Synonyms: | FSA-1, ACRP, MGC20134 |
Description: | sperm associated antigen 7 |
UTRs: | 6 UTRs found |
Name: | VPS37A |
Synonyms: | FLJ32642, HCRP1,PQBP2 |
Description: | vacuolar protein sorting 37 homolog A (S. cerevisiae) |
Gene function: | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. |
UTRs: | 6 UTRs found |