What is AURA ?

The Atlas of UTR Regulatory Activity (AURA) is a manually curated and comprehensive catalog of human UTRs and UTR regulatory annotations. Through its intuitive web interface, it provides full access to a wealth of information that integrates RNA sequence and structure data, regulatory and variation sites, gene synteny, gene and protein expression and gene functional descriptions from scientific literature and specialized databases, all exploitable through its various data mining tools.

Who are we?

The Laboratory of Translational Genomics (LTG) is part of the Centre for Integrative Biology (CIBIO) at the University of Trento: a newly established biomedicine research centre. It is a mixed "dry/wet biology" laboratory devoted to the study of translational control networks in both cell physiology and disease, primarily, but not exclusively, cancer. It has 18 members (4 PhD students, 3 first level and 10 experienced postdocs, 1 staff scientist) whose expertise ranges from computational biology to biochemistry, molecular biology, biophysics, computer science, plus 3 additional undergraduates. Its mission is to look for a synthesis between fundamental research in cell structure and function and translational biomedicine. LTG pursues this aim by improving the existing profiling methods of gene expression variations and by looking for the chemical changes that actually impact on the phenotype through crossing-edge tools and computational approaches. The core techniques for this effort are cell separation methods for polysomal mRNA, which LTG is adapting both to tissue samples and to high-throughput settings. LTG introduces the translatome profiling by microarray and by next generation sequencing as a very effective proxy of proteome profiling.

Some statistics about AURA

Organisms

Basic annotation

UTRs: 224501
5'UTRs: 113545
3'UTRs: 110956
UTR secondary structures: 198071
Transcripts: 110350
Genes: 70559

Regulatory annotation

Regulatory sites: 2813391
RBPs: 236
miRNAs: 985
Cis elements: 54783
Variations: 1043170
Transcripts halve-lives: 46089

Data sources

Referenced papers: 2261
Included databases: 12
On-the-fly databases: 1